The VAO/PCMH flavoprotein family.
Arch Biochem Biophys
; 632: 104-117, 2017 10 15.
Article
em En
| MEDLINE
| ID: mdl-28669855
ABSTRACT
The VAO/PCMH flavoprotein family consists of structurally homologous flavin-dependent enzymes that catalyze a wide range of chemical reactions. Family members share an architecture consisting of a conserved FAD-binding domain and a more variable substrate-binding domain, which enables varying interactions with a range of substrates while maintaining the same cofactor-binding fold. Here, we provide an overview of the current state of our knowledge on the members of the VAO/PCMH family. Based on a phylogenetic analysis, we divide the family into 11 subgroups. We discuss the properties of these subgroups, focusing on recent developments in terms of the discovery of new family members and mechanistic advances. We also highlight open questions that will provide challenges for future research.
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Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Filogenia
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Proteínas de Bactérias
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Parede Celular
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Oxirredutases do Álcool
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Flavoproteínas
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Mycobacterium tuberculosis
Idioma:
En
Revista:
Arch Biochem Biophys
Ano de publicação:
2017
Tipo de documento:
Article