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Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition.
Ono, Akito; Sano, Osamu; Kazetani, Ken-Ichi; Muraki, Takamichi; Imamura, Keisuke; Sumi, Hiroyuki; Matsui, Junji; Iwata, Hidehisa.
Afiliação
  • Ono A; Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Kanagawa, Japan.
  • Sano O; Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Kanagawa, Japan.
  • Kazetani KI; Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Kanagawa, Japan.
  • Muraki T; Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Kanagawa, Japan.
  • Imamura K; Oncology Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Kanagawa, Japan.
  • Sumi H; Oncology Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Kanagawa, Japan.
  • Matsui J; Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Kanagawa, Japan.
  • Iwata H; Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Kanagawa, Japan.
PLoS One ; 12(7): e0181243, 2017.
Article em En | MEDLINE | ID: mdl-28704514
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxidiazóis / Piridazinas / Autofagia / Estearoil-CoA Dessaturase / Resistencia a Medicamentos Antineoplásicos / Proliferação de Células / Proteínas Quinases Ativadas por AMP / Inibidores do Crescimento Limite: Humans Idioma: En Revista: PLoS One Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxidiazóis / Piridazinas / Autofagia / Estearoil-CoA Dessaturase / Resistencia a Medicamentos Antineoplásicos / Proliferação de Células / Proteínas Quinases Ativadas por AMP / Inibidores do Crescimento Limite: Humans Idioma: En Revista: PLoS One Ano de publicação: 2017 Tipo de documento: Article