Metabolic response of porcine colon explants to in vitro infection by Brachyspira hyodysenteriae: a leap into disease pathophysiology.
Metabolomics
; 13(7): 83, 2017.
Article
em En
| MEDLINE
| ID: mdl-28706469
ABSTRACT
INTRODUCTION:
Swine dysentery caused by Brachyspira hyodysenteriae is a production limiting disease in pig farming. Currently antimicrobial therapy is the only treatment and control method available.OBJECTIVE:
The aim of this study was to characterize the metabolic response of porcine colon explants to infection by B. hyodysenteriae.METHODS:
Porcine colon explants exposed to B. hyodysenteriae were analyzed for histopathological, metabolic and pro-inflammatory gene expression changes.RESULTS:
Significant epithelial necrosis, increased levels of l-citrulline and IL-1α were observed on explants infected with B. hyodysenteriae.CONCLUSIONS:
The spirochete induces necrosis in vitro likely through an inflammatory process mediated by IL-1α and NO.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Idioma:
En
Revista:
Metabolomics
Ano de publicação:
2017
Tipo de documento:
Article