Melittin exerts an antitumor effect on nonsmall cell lung cancer cells.
Mol Med Rep
; 16(3): 3581-3586, 2017 Sep.
Article
em En
| MEDLINE
| ID: mdl-28713976
ABSTRACT
Lung cancer accounts for a significant percentage of all cancerassociated mortalities in men and women, with nonsmall cell lung cancer being the most frequently occurring type of lung cancer. Melittin is the principal active component of apitoxin (bee venom) that has been reported to exert antichronic inflammatory and anticancer effects. In the present study, the antitumor effect of melittin was evaluated using in vivo and in vitro analyses. The results demonstrated that melittin significantly inhibited the epidermal growth factorinduced invasion and migration of nonsmall cell lung cancer cells. Subcutaneous injection of melittin at doses of 1 and 10 mg/kg significantly suppressed nonsmall cell lung cancer tumor growth by 27 and 61%, respectively. In addition, melittin significantly inhibited the secretion of vascular endothelial growth factor (VEGF) in nonsmall cell lung cancer cells. Furthermore, melittin decreased the protein expression of VEGF and hypoxiainducible factor 1α. Therefore, the antitumor activity of melittin may be associated with the antiangiogenic actions of inhibiting the VEGF and hypoxiainducible factor signaling pathways.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma Pulmonar de Células não Pequenas
/
Neoplasias Pulmonares
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Meliteno
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Antineoplásicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Mol Med Rep
Ano de publicação:
2017
Tipo de documento:
Article