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A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.
O'Rourke, Donald M; Nasrallah, MacLean P; Desai, Arati; Melenhorst, Jan J; Mansfield, Keith; Morrissette, Jennifer J D; Martinez-Lage, Maria; Brem, Steven; Maloney, Eileen; Shen, Angela; Isaacs, Randi; Mohan, Suyash; Plesa, Gabriela; Lacey, Simon F; Navenot, Jean-Marc; Zheng, Zhaohui; Levine, Bruce L; Okada, Hideho; June, Carl H; Brogdon, Jennifer L; Maus, Marcela V.
Afiliação
  • O'Rourke DM; Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Nasrallah MP; Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Desai A; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Melenhorst JJ; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Mansfield K; Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
  • Morrissette JJD; Division of Precision and Computational Diagnostics, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Martinez-Lage M; Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Brem S; Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Maloney E; Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Shen A; Novartis Oncology, East Hanover, NJ 07936, USA.
  • Isaacs R; Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
  • Mohan S; Division of Neuroradiology, Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Plesa G; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Lacey SF; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Navenot JM; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Zheng Z; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Levine BL; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Okada H; Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143, USA.
  • June CH; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Brogdon JL; Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
  • Maus MV; Cellular Immunotherapy Program, Cancer Center and Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA. mvmaus@mgh.harvard.edu.
Sci Transl Med ; 9(399)2017 07 19.
Article em En | MEDLINE | ID: mdl-28724573
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Antígenos de Linfócitos T / Glioblastoma / Receptores ErbB / Recidiva Local de Neoplasia Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Transl Med Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Antígenos de Linfócitos T / Glioblastoma / Receptores ErbB / Recidiva Local de Neoplasia Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Transl Med Ano de publicação: 2017 Tipo de documento: Article