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The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase.
Gajiwala, Ketan S; Grodsky, Neil; Bolaños, Ben; Feng, Junli; Ferre, RoseAnn; Timofeevski, Sergei; Xu, Meirong; Murray, Brion W; Johnson, Ted W; Stewart, Al.
Afiliação
  • Gajiwala KS; From Oncology Medicinal Chemistry and ketan.gajiwala@pfizer.com.
  • Grodsky N; From Oncology Medicinal Chemistry and.
  • Bolaños B; From Oncology Medicinal Chemistry and.
  • Feng J; From Oncology Medicinal Chemistry and.
  • Ferre R; From Oncology Medicinal Chemistry and.
  • Timofeevski S; Oncology Research and Development, Pfizer Worldwide Research and Development, San Diego, California 92121.
  • Xu M; Oncology Research and Development, Pfizer Worldwide Research and Development, San Diego, California 92121.
  • Murray BW; Oncology Research and Development, Pfizer Worldwide Research and Development, San Diego, California 92121.
  • Johnson TW; From Oncology Medicinal Chemistry and.
  • Stewart A; From Oncology Medicinal Chemistry and.
J Biol Chem ; 292(38): 15705-15716, 2017 09 22.
Article em En | MEDLINE | ID: mdl-28724631
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas / Receptores Proteína Tirosina Quinases / Compostos Macrocíclicos / Inibidores de Proteínas Quinases Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas / Receptores Proteína Tirosina Quinases / Compostos Macrocíclicos / Inibidores de Proteínas Quinases Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2017 Tipo de documento: Article