Dramatic response of acute disseminated intravascular coagulation to erlotinib in a patient with lung adenocarcinoma with activating EGFR mutation.
J Int Med Res
; 46(1): 533-537, 2018 Jan.
Article
em En
| MEDLINE
| ID: mdl-28730909
ABSTRACT
Disseminated intravascular coagulation (DIC) is a commonly encountered clinical situation characterized by thrombotic occlusion or bleeding in patients with lung cancer. DIC in patients with cancer is usually asymptomatic, taking a chronic form as a compensatory mechanism. Although acute DIC in patients with lung cancer is rarely reported, it can be fatal. We herein describe a patient with lung adenocarcinoma with an activating mutation of the epidermal growth factor receptor (EGFR) gene who developed acute DIC after minor surgical excision. The patient's condition dramatically improved immediately after administration of erlotinib. This report alerts physicians to the occurrence of acute DIC and serves as a reference in treating EGFR mutation-positive lung cancer in patients with DIC.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma Basocelular
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Adenocarcinoma
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Inibidores de Proteínas Quinases
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Coagulação Intravascular Disseminada
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Receptores ErbB
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Cloridrato de Erlotinib
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Neoplasias Pulmonares
Limite:
Aged80
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Humans
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Male
Idioma:
En
Revista:
J Int Med Res
Ano de publicação:
2018
Tipo de documento:
Article