Post-hypoxia Invasion of the fetal brain by multidrug resistant Staphylococcus.
Sci Rep
; 7(1): 6458, 2017 07 25.
Article
em En
| MEDLINE
| ID: mdl-28743956
ABSTRACT
Herein we describe an association between activation of inflammatory pathways following transient hypoxia and the appearance of the multidrug resistant bacteria Staphylococcus simulans in the fetal brain. Reduction of maternal arterial oxygen tension by 50% over 30 min resulted in a subseiuent significant over-expression of genes associated with immune responses 24 h later in the fetal brain. The activated genes were consistent with stimulation by bacterial lipopolysaccharide; an influx of macrophages and appearance of live bacteria were found in these fetal brains. S. simulans was the predominant bacterial species in fetal brain after hypoxia, but was found in placenta of all animals. Strains of S. simulans from the placenta and fetal brain were equally highly resistant to multiple antibiotics including methicillin and had identical genome sequences. These results suggest that bacteria from the placenta invade the fetal brain after maternal hypoxia.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Placenta
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Staphylococcus
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Encéfalo
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Farmacorresistência Bacteriana Múltipla
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Hipóxia Fetal
Limite:
Animals
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Pregnancy
Idioma:
En
Revista:
Sci Rep
Ano de publicação:
2017
Tipo de documento:
Article