Your browser doesn't support javascript.
loading
Melanopsin ganglion cell outer retinal dendrites: Morphologically distinct and asymmetrically distributed in the mouse retina.
Sondereker, Katelyn B; Onyak, Jessica R; Islam, Shakib W; Ross, Christopher L; Renna, Jordan M.
Afiliação
  • Sondereker KB; Department of Biology, The University of Akron, Akron, Ohio.
  • Onyak JR; Department of Biology, The University of Akron, Akron, Ohio.
  • Islam SW; Department of Biology, The University of Akron, Akron, Ohio.
  • Ross CL; Department of Biology, The University of Akron, Akron, Ohio.
  • Renna JM; Department of Biology, The University of Akron, Akron, Ohio.
J Comp Neurol ; 525(17): 3653-3665, 2017 Dec 01.
Article em En | MEDLINE | ID: mdl-28758193
ABSTRACT
A small population of retinal ganglion cells expresses the photopigment melanopsin and function as autonomous photoreceptors. They encode global luminance levels critical for light-mediated non-image forming visual processes including circadian rhythms and the pupillary light reflex. There are five melanopsin ganglion cell subtypes (M1-M5). M1 and displaced M1 (M1d) cells have dendrites that ramify within the outermost layer of the inner plexiform layer. It was recently discovered that some melanopsin ganglion cells extend dendrites into the outer retina. Outer Retinal Dendrites (ORDs) either ramify within the outer plexiform layer (OPL) or the inner nuclear layer, and while present in the mature retina, are most abundant postnatally. Anatomical evidence for synaptic transmission between cone photoreceptor terminals and ORDs suggests a novel photoreceptor to ganglion cell connection in the mammalian retina. While it is known that the number of ORDs in the retina is developmentally regulated, little is known about the morphology, the cells from which they originate, or their spatial distribution throughout the retina. We analyzed the morphology of melanopsin-immunopositive ORDs in the OPL at different developmental time points in the mouse retina and identified five types of ORDs originating from either M1 or M1d cells. However, a pattern emerges within these ORDs from M1d cells are generally longer and more highly branched than ORDs from conventional M1 cells. Additionally, we found ORDs asymmetrically distributed to the dorsal retina. This morphological analysis provides the first step in identifying a potential role for biplexiform melanopsin ganglion cell ORDs.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retina / Células Ganglionares da Retina / Opsinas de Bastonetes / Dendritos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Comp Neurol Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retina / Células Ganglionares da Retina / Opsinas de Bastonetes / Dendritos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Comp Neurol Ano de publicação: 2017 Tipo de documento: Article