Paths from DNA damage and signaling to genome rearrangements via homologous recombination.
Mutat Res
; 806: 64-74, 2017 12.
Article
em En
| MEDLINE
| ID: mdl-28779875
ABSTRACT
DNA damage is a constant threat to genome integrity. DNA repair and damage signaling networks play a central role maintaining genome stability, suppressing tumorigenesis, and determining tumor response to common cancer chemotherapeutic agents and radiotherapy. DNA double-strand breaks (DSBs) are critical lesions induced by ionizing radiation and when replication forks encounter damage. DSBs can result in mutations and large-scale genome rearrangements reflecting mis-repair by non-homologous end joining or homologous recombination. Ionizing radiation induces genetic change immediately, and it also triggers delayed events weeks or even years after exposure, long after the initial damage has been repaired or diluted through cell division. This review covers DNA damage signaling and repair pathways and cell fate following genotoxic insult, including immediate and delayed genome instability and cell survival/cell death pathways.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
Rearranjo Gênico
/
Transdução de Sinais
/
Genoma Humano
/
Instabilidade Genômica
/
Recombinação Homóloga
Limite:
Humans
Idioma:
En
Revista:
Mutat Res
Ano de publicação:
2017
Tipo de documento:
Article