Downregulation of LGR5 Expression Inhibits Cardiomyocyte Differentiation and Potentiates Endothelial Differentiation from Human Pluripotent Stem Cells.

Jha, Rajneesh; Singh, Monalisa; Wu, Qingling; Gentillon, Cinsley; Preininger, Marcela K; Xu, Chunhui

Jha, Rajneesh; Singh, Monalisa; Wu, Qingling; Gentillon, Cinsley; Preininger, Marcela K; Xu, Chunhui.

Afiliação

Jha R; Division of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 2015 Uppergate Drive, Atlanta, GA 30322, USA.
Singh M; Division of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 2015 Uppergate Drive, Atlanta, GA 30322, USA.
Wu Q; Division of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 2015 Uppergate Drive, Atlanta, GA 30322, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta,
Gentillon C; Division of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 2015 Uppergate Drive, Atlanta, GA 30322, USA.
Preininger MK; Division of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 2015 Uppergate Drive, Atlanta, GA 30322, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta,
Xu C; Division of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 2015 Uppergate Drive, Atlanta, GA 30322, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta,

Stem Cell Reports ; 9(2): 513-527, 2017 08 08.

Article em En | MEDLINE | ID: mdl-28793247

Assuntos

Diferenciação Celular/genética; Células Endoteliais/citologia; Células Endoteliais/metabolismo; Regulação da Expressão Gênica no Desenvolvimento; Miócitos Cardíacos/citologia; Miócitos Cardíacos/metabolismo; Células-Tronco Pluripotentes/citologia; Células-Tronco Pluripotentes/metabolismo; Receptores Acoplados a Proteínas G/genética; Padronização Corporal/genética; Proliferação de Células; Técnicas de Silenciamento de Genes; Humanos; Mesoderma/citologia; Mesoderma/embriologia; Via de Sinalização Wnt

Palavras-chave

LGR5; Wnt signaling; cardiomyocytes; differentiation; embryonic stem cells; endothelial cells; gene expression; induced pluripotent stem cells; mesoderm patterning; proliferation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diferenciação Celular / Regulação da Expressão Gênica no Desenvolvimento / Miócitos Cardíacos / Células-Tronco Pluripotentes / Células Endoteliais / Receptores Acoplados a Proteínas G Limite: Humans Idioma: En Revista: Stem Cell Reports Ano de publicação: 2017 Tipo de documento: Article

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