Differential transcriptome of tolerogenic versus inflammatory dendritic cells points to modulated T1D genetic risk and enriched immune regulation.

Nikolic, T; Woittiez, N J C; van der Slik, A; Laban, S; Joosten, A; Gysemans, C; Mathieu, C; Zwaginga, J J; Koeleman, B; Roep, B O

Nikolic, T; Woittiez, N J C; van der Slik, A; Laban, S; Joosten, A; Gysemans, C; Mathieu, C; Zwaginga, J J; Koeleman, B; Roep, B O.

Afiliação

Nikolic T; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Woittiez NJC; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center (LUMC), Leiden, The Netherlands.
van der Slik A; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Laban S; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Joosten A; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Gysemans C; Department of Clinical and Experimental Endocrinology, University of Leuven, Leuven, Belgium.
Mathieu C; Department of Clinical and Experimental Endocrinology, University of Leuven, Leuven, Belgium.
Zwaginga JJ; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Koeleman B; Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
Roep BO; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center (LUMC), Leiden, The Netherlands.

Genes Immun ; 18(3): 176-183, 2017 09.

Article em En | MEDLINE | ID: mdl-28794505

Assuntos

Autoimunidade/genética; Células Dendríticas/imunologia; Diabetes Mellitus Tipo 1/genética; Tolerância Imunológica/genética; Transcriptoma; Apresentação de Antígeno/genética; Antígeno B7-2/genética; Antígeno B7-2/metabolismo; Antígeno CD52/genética; Antígeno CD52/metabolismo; Calcitriol/farmacologia; Linhagem Celular; Células Cultivadas; Células Dendríticas/efeitos dos fármacos; Dexametasona/farmacologia; Diabetes Mellitus Tipo 1/imunologia; Humanos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Dendríticas / Autoimunidade / Diabetes Mellitus Tipo 1 / Transcriptoma / Tolerância Imunológica Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Genes Immun Ano de publicação: 2017 Tipo de documento: Article

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