Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.

Wang, Jin; Cai, Pei; Yang, Xue-Lian; Li, Fan; Wu, Jia-Jia; Kong, Ling-Yi; Wang, Xiao-Bing

Wang, Jin; Cai, Pei; Yang, Xue-Lian; Li, Fan; Wu, Jia-Jia; Kong, Ling-Yi; Wang, Xiao-Bing.

Afiliação

Wang J; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
Cai P; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
Yang XL; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
Li F; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
Wu JJ; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
Kong LY; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China. Electronic address: cpu_lykong@126.com.
Wang XB; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China. Electronic address: xbwang@cpu.edu.cn.

Eur J Med Chem ; 139: 68-83, 2017 Oct 20.

Article em En | MEDLINE | ID: mdl-28800459

Assuntos

Doença de Alzheimer/tratamento farmacológico; Antioxidantes/farmacologia; Benzilaminas/farmacologia; Colinérgicos/farmacologia; Inibidores da Colinesterase/farmacologia; Cinamatos/farmacologia; Fármacos Neuroprotetores/farmacologia; Acetilcolinesterase/metabolismo; Animais; Antioxidantes/síntese química; Antioxidantes/química; Benzilaminas/química; Barreira Hematorretiniana/efeitos dos fármacos; Butirilcolinesterase/metabolismo; Morte Celular/efeitos dos fármacos; Colinérgicos/síntese química; Colinérgicos/química; Inibidores da Colinesterase/síntese química; Inibidores da Colinesterase/química; Cinamatos/química; Relação Dose-Resposta a Droga; Humanos; Estrutura Molecular; Fármacos Neuroprotetores/síntese química; Fármacos Neuroprotetores/química; Estresse Oxidativo/efeitos dos fármacos; Células PC12; Ratos; Relação Estrutura-Atividade

Palavras-chave

AP2238; Alzheimer's disease; Antioxidant activity; Cholinesterase; Cinnamamide

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Benzilaminas / Inibidores da Colinesterase / Cinamatos / Fármacos Neuroprotetores / Colinérgicos / Doença de Alzheimer / Antioxidantes Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2017 Tipo de documento: Article

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