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Targeting of CDK9 with indirubin 3'-monoxime safely and durably reduces HIV viremia in chronically infected humanized mice.
Medina-Moreno, Sandra; Dowling, Thomas C; Zapata, Juan C; Le, Nhut M; Sausville, Edward; Bryant, Joseph; Redfield, Robert R; Heredia, Alonso.
Afiliação
  • Medina-Moreno S; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
  • Dowling TC; Department of Pharmaceutical Sciences, Ferris State University, Grand Rapids, Michigan, United States of America.
  • Zapata JC; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
  • Le NM; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
  • Sausville E; Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
  • Bryant J; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
  • Redfield RR; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
  • Heredia A; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
PLoS One ; 12(8): e0183425, 2017.
Article em En | MEDLINE | ID: mdl-28817720
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oximas / Viremia / HIV-1 / Fármacos Anti-HIV / Carga Viral / Quinase 9 Dependente de Ciclina / Inibidores de Proteínas Quinases / Indóis Limite: Animals / Humans Idioma: En Revista: PLoS One Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oximas / Viremia / HIV-1 / Fármacos Anti-HIV / Carga Viral / Quinase 9 Dependente de Ciclina / Inibidores de Proteínas Quinases / Indóis Limite: Animals / Humans Idioma: En Revista: PLoS One Ano de publicação: 2017 Tipo de documento: Article