Flavones. 1. Synthesis and antihypertensive activity of (3-phenylflavonoxy)propanolamines without beta-adrenoceptor antagonism.
J Med Chem
; 30(5): 788-92, 1987 May.
Article
em En
| MEDLINE
| ID: mdl-2883317
ABSTRACT
The synthesis of a series of (3-phenylflavonoxy)propanolamines is described. These compounds were evaluated for potential antihypertensive activity in spontaneously hypertensive rats, as well as for in vivo and in vitro evidence of beta-adrenoceptor antagonism. Some of the compounds of this series exhibited effective antihypertensive properties but did not antagonize beta-adrenergic receptors. These active compounds represent a unique series of effective antihypertensive agents that, despite possessing structural characteristics typical of beta-blockers, does not have beta-adrenergic receptor blocking activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propanolaminas
/
Flavonoides
/
Receptores Adrenérgicos beta
/
Hipertensão
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Ano de publicação:
1987
Tipo de documento:
Article