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Life years lost attributable to late effects after radiotherapy for early stage Hodgkin lymphoma: The impact of proton therapy and/or deep inspiration breath hold.
Rechner, Laura Ann; Maraldo, Maja Vestmø; Vogelius, Ivan Richter; Zhu, Xiaorong Ronald; Dabaja, Bouthaina Shbib; Brodin, Nils Patrik; Petersen, Peter Meidahl; Specht, Lena; Aznar, Marianne Camille.
Afiliação
  • Rechner LA; Department of Oncology, Rigshospitalet, University of Copenhagen, Denmark; Niels Bohr Insitute, University of Copenhagen, Denmark. Electronic address: laura.ann.rechner@regionh.dk.
  • Maraldo MV; Department of Oncology, Rigshospitalet, University of Copenhagen, Denmark.
  • Vogelius IR; Department of Oncology, Rigshospitalet, University of Copenhagen, Denmark.
  • Zhu XR; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, USA.
  • Dabaja BS; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.
  • Brodin NP; Institute for Onco-Physics, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, USA.
  • Petersen PM; Department of Oncology, Rigshospitalet, University of Copenhagen, Denmark.
  • Specht L; Department of Oncology, Rigshospitalet, University of Copenhagen, Denmark.
  • Aznar MC; Niels Bohr Insitute, University of Copenhagen, Denmark; Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Radiother Oncol ; 125(1): 41-47, 2017 10.
Article em En | MEDLINE | ID: mdl-28838605
BACKGROUND AND PURPOSE: Due to the long life expectancy after treatment, the risk of late effects after radiotherapy (RT) is of particular importance for patients with Hodgkin lymphoma (HL). Both deep inspiration breath hold (DIBH) and proton therapy have been shown to reduce the dose to normal tissues for mediastinal HL, but the impact of these techniques in combination is unknown. The purpose of this study was to compare the life years lost (LYL) attributable to late effects after RT for mediastinal HL using intensity modulated radiation therapy (IMRT) in free breathing (FB) and DIBH, and proton therapy in FB and DIBH. MATERIALS AND METHODS: Plans for each technique were created for 22 patients with HL. Doses were extracted and the risk of late effects and LYL were estimated. RESULTS: We found that the use of DIBH, proton therapy, and the combination significantly reduced the LYL compared to IMRT in FB. The lowest LYL was found for proton therapy in DIBH. However, when IMRT in DIBH was compared to proton therapy in FB, no significant difference was found. CONCLUSIONS: Patient-specific plan comparisons should be used to select the optimal technique when comparing IMRT in DIBH and proton therapy in FB.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Hodgkin / Terapia com Prótons / Suspensão da Respiração Aspecto: Patient_preference Limite: Humans Idioma: En Revista: Radiother Oncol Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Hodgkin / Terapia com Prótons / Suspensão da Respiração Aspecto: Patient_preference Limite: Humans Idioma: En Revista: Radiother Oncol Ano de publicação: 2017 Tipo de documento: Article