Helminths: an unrecognised disease burden prevalent among migrants in the gastroenterology clinic.
Frontline Gastroenterol
; 2(2): 124-129, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-28839594
ABSTRACT
OBJECTIVE:
To estimate the prevalence of, and implement a diagnostic strategy for, imported helminth infection in the gastroenterology clinic.DESIGN:
A retrospective study of eosinophil count and probable tropical exposure (phase I) followed by a prospective study of parasitological investigation (phase II).SETTING:
Gastroenterology service of an inner London hospital. PATIENTS Adult patients newly attending general gastroenterology and inflammatory bowel disease clinics.INTERVENTIONS:
In phase I, evidence of undiagnosed helminth infection was sought by analysing patient records for associations between eosinophil count and ethnicity. In phase II, a UK guideline for investigation of eosinophilia in migrants was implemented and diagnostic yield determined. MAIN OUTCOMEMEASURES:
In phase I, prevalence of eosinophilia was determined; in phase II, helminth prevalence and degree of eosinophilia before and after treatment were reported. Information on symptomatic response to treatment was recorded. Ethnicity was used as a proxy measure for tropical exposure.RESULTS:
426 new patients attended in a 12 month period. Eosinophilia was present in 27 (6.3%). 10/27 (37.0%) patients with eosinophilia were of African or Asian ethnicity whereas only 20% (85/426) of patients overall were from these ethnic groups (χ2=5.27, p=0.02). Following implementation of the protocol, 25/36 migrants with eosinophilia attended for parasitological investigations. Helminth infection was diagnosed in 10/25 (40%). Strongyloidiasis (six patients) and schistosomiasis (three patients) were the most common diagnoses. Median eosinophil count was 1.06×109/l in those with helminths and 0.58×109/l in those without (p=0.004). Eosinophil counts normalised in, and symptomatic improvement was reported by, most patients after treatment.CONCLUSIONS:
Eosinophilia is associated with African or Asian ethnicity in an inner city gastroenterology service. This association is probably explained by imported helminths, which are prevalent in this setting, may be a cause of gastrointestinal symptoms and is easily diagnosed and treated by standard protocols.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Tipo de estudo:
Guideline
/
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Frontline Gastroenterol
Ano de publicação:
2011
Tipo de documento:
Article