Therapeutic Gene Editing Safety and Specificity.
Hematol Oncol Clin North Am
; 31(5): 787-795, 2017 10.
Article
em En
| MEDLINE
| ID: mdl-28895847
ABSTRACT
Therapeutic gene editing is significant for medical advancement. Safety is intricately linked to the specificity of the editing tools used to cut at precise genomic targets. Improvements can be achieved by thoughtful design of nucleases and repair templates, analysis of off-target editing, and careful utilization of viral vectors. Advancements in DNA repair mechanisms and development of new generations of tools improve targeting of specific sequences while minimizing risks. It is important to plot a safe course for future clinical trials. This article reviews safety and specificity for therapeutic gene editing to spur dialogue and advancement.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terapia Genética
/
Edição de Genes
/
Vetores Genéticos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Hematol Oncol Clin North Am
Ano de publicação:
2017
Tipo de documento:
Article