Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis.

Wei, Q; Ye, Z; Zhong, X; Li, L; Wang, C; Myers, R E; Palazzo, J P; Fortuna, D; Yan, A; Waldman, S A; Chen, X; Posey, J A; Basu-Mallick, A; Jiang, B H; Hou, L; Shu, J; Sun, Y; Xing, J; Li, B; Yang, H

Wei, Q; Ye, Z; Zhong, X; Li, L; Wang, C; Myers, R E; Palazzo, J P; Fortuna, D; Yan, A; Waldman, S A; Chen, X; Posey, J A; Basu-Mallick, A; Jiang, B H; Hou, L; Shu, J; Sun, Y; Xing, J; Li, B; Yang, H.

Afiliação

Wei Q; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville.
Ye Z; Department of Medical Oncology, Thomas Jefferson University, Philadelphia.
Zhong X; Department of Medicine, Vanderbilt University, Nashville.
Li L; Department of Medical Oncology, Thomas Jefferson University, Philadelphia.
Wang C; Department of Medical Oncology, Thomas Jefferson University, Philadelphia.
Myers RE; Department of Medical Oncology, Thomas Jefferson University, Philadelphia.
Palazzo JP; Pathology, Anatomy and Cell Biology.
Fortuna D; Pathology, Anatomy and Cell Biology.
Yan A; Department of Medical Oncology, Thomas Jefferson University, Philadelphia.
Waldman SA; Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia.
Chen X; Department of Public Health Sciences, University of Miami, Miami.
Posey JA; Department of Medical Oncology, Thomas Jefferson University, Philadelphia.
Basu-Mallick A; Department of Medical Oncology, Thomas Jefferson University, Philadelphia.
Jiang BH; Pathology, Anatomy and Cell Biology.
Hou L; Department of Preventive Medicine, Northwestern University, Chicago, USA.
Shu J; Department of Medical Oncology, Thomas Jefferson University, Philadelphia.
Sun Y; Department of Medical Oncology, Anhui Provincial Hospital, Hefei.
Xing J; Department of Experimental Teaching Center of Basic Medicine, Fourth Military Medical University, Xi'an, China.
Li B; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville.
Yang H; Department of Medical Oncology, Thomas Jefferson University, Philadelphia.

Ann Oncol ; 28(9): 2135-2141, 2017 Sep 01.

Article em En | MEDLINE | ID: mdl-28911083

Assuntos

Neoplasias Colorretais/patologia; Sequenciamento do Exoma; Heterogeneidade Genética; Metástase Neoplásica/genética; Neoplasias Colorretais/genética; Humanos; Mutação; Inoculação de Neoplasia

Palavras-chave

colorectal cancer; heterogeneity; metastasis; whole-exome sequencing

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Heterogeneidade Genética / Sequenciamento do Exoma / Metástase Neoplásica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Ann Oncol Ano de publicação: 2017 Tipo de documento: Article

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