CHEMGENIE: integration of chemogenomics data for applications in chemical biology.
Drug Discov Today
; 23(1): 151-160, 2018 01.
Article
em En
| MEDLINE
| ID: mdl-28917822
ABSTRACT
Increasing amounts of biological data are accumulating in the pharmaceutical industry and academic institutions. However, data does not equal actionable information, and guidelines for appropriate data capture, harmonization, integration, mining, and visualization need to be established to fully harness its potential. Here, we describe ongoing efforts at Merck & Co. to structure data in the area of chemogenomics. We are integrating complementary data from both internal and external data sources into one chemogenomics database (Chemical Genetic Interaction Enterprise; CHEMGENIE). Here, we demonstrate how this well-curated database facilitates compound set design, tool compound selection, target deconvolution in phenotypic screening, and predictive model building.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bases de Dados Factuais
/
Genômica
/
Descoberta de Drogas
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Drug Discov Today
Ano de publicação:
2018
Tipo de documento:
Article