Development of a method for the preparation of zirconium-89 radiolabelled chitosan nanoparticles as an application for leukocyte trafficking with positron emission tomography.
Appl Radiat Isot
; 130: 7-12, 2017 12.
Article
em En
| MEDLINE
| ID: mdl-28923298
ABSTRACT
Positron Emission Tomography is an attractive imaging modality for monitoring the migration of cells to pathological tissue. We evaluated a new method for radiolabelling leukocytes with zirconium-89 (89Zr) using chitosan nanoparticles (CN, Z-average size 343 ± 210nm and zeta potential +46 ± 4mV) as the carrier. We propose that cell uptake of 89Zr-loaded CN occurred in a two-step process; cell membrane interaction with 89Zr-loaded CN was followed by a slower cell internalisation step.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Radioisótopos
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Zircônio
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Quimiotaxia de Leucócito
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Quitosana
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Tomografia por Emissão de Pósitrons
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Nanopartículas
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Leucócitos
Limite:
Humans
Idioma:
En
Revista:
Appl Radiat Isot
Ano de publicação:
2017
Tipo de documento:
Article