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ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157.
Feuerbach, Dominik; Schindler, Patrick; Barske, Carmen; Joller, Stefanie; Beng-Louka, Edwige; Worringer, Katie A; Kommineni, Sravya; Kaykas, Ajamete; Ho, Daniel J; Ye, Chaoyang; Welzenbach, Karl; Elain, Gaelle; Klein, Laurent; Brzak, Irena; Mir, Anis K; Farady, Christopher J; Aichholz, Reiner; Popp, Simone; George, Nathalie; Neumann, Ulf.
Afiliação
  • Feuerbach D; Neuroscience Research, Novartis Institutes for Biomedical Research, Basel, Switzerland. Electronic address: dominik.feuerbach@novartis.com.
  • Schindler P; Biologics Center, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Barske C; Neuroscience Research, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Joller S; Neuroscience Research, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Beng-Louka E; Biologics Center, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Worringer KA; Neuroscience Research, Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Kommineni S; Neuroscience Research, Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Kaykas A; Neuroscience Research, Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Ho DJ; Neuroscience Research, Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Ye C; Neuroscience Research, Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Welzenbach K; Autoimmunity, Transplantation & Inflammation, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Elain G; Autoimmunity, Transplantation & Inflammation, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Klein L; Autoimmunity, Transplantation & Inflammation, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Brzak I; Neuroscience Research, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Mir AK; Autoimmunity, Transplantation & Inflammation, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Farady CJ; Autoimmunity, Transplantation & Inflammation, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Aichholz R; PK Sciences Department, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Popp S; Biologics Center, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • George N; Biologics Center, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Neumann U; Neuroscience Research, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Neurosci Lett ; 660: 109-114, 2017 Nov 01.
Article em En | MEDLINE | ID: mdl-28923481
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Receptores Imunológicos / Proteína ADAM17 / Histidina Limite: Animals / Humans Idioma: En Revista: Neurosci Lett Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Receptores Imunológicos / Proteína ADAM17 / Histidina Limite: Animals / Humans Idioma: En Revista: Neurosci Lett Ano de publicação: 2017 Tipo de documento: Article