A hydrogel matrix prolongs persistence and promotes specific localization of an oncolytic adenovirus in a tumor by restricting nonspecific shedding and an antiviral immune response.

Jung, Bo-Kyeong; Oh, Eonju; Hong, JinWoo; Lee, Yunki; Park, Ki Dong; Yun, Chae-Ok

Jung, Bo-Kyeong; Oh, Eonju; Hong, JinWoo; Lee, Yunki; Park, Ki Dong; Yun, Chae-Ok.

Afiliação

Jung BK; Department of Bioengineering, College of Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea.
Oh E; Department of Bioengineering, College of Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea.
Hong J; Department of Bioengineering, College of Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea.
Lee Y; Department of Molecular Science and Technology, Ajou University, 5 Woncheon, Yeongtong, Suwon 443-749, Republic of Korea.
Park KD; Department of Molecular Science and Technology, Ajou University, 5 Woncheon, Yeongtong, Suwon 443-749, Republic of Korea.
Yun CO; Department of Bioengineering, College of Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea. Electronic address: chaeok@hanyang.ac.kr.

Biomaterials ; 147: 26-38, 2017 Dec.

Article em En | MEDLINE | ID: mdl-28923683

Assuntos

Adenoviridae/genética; Gelatina/química; Hidrogéis/química; Vírus Oncolíticos; Ligante Indutor de Apoptose Relacionado a TNF/genética; Adenoviridae/imunologia; Animais; Apoptose; Linhagem Celular; Linhagem Celular Tumoral; Proliferação de Células; Cricetinae; Humanos; Imunidade Ativa; Injeções Intralesionais; Mesocricetus; Transplante de Neoplasias; Terapia Viral Oncolítica; Vírus Oncolíticos/genética; Vírus Oncolíticos/imunologia; Eliminação de Partículas Virais

Palavras-chave

Antitumor immune response; Antiviral immune response; Cancer gene therapy; Gelatin hydrogel; Oncolytic adenovirus; Sustained release; Syrian hamster model

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenoviridae / Hidrogéis / Vírus Oncolíticos / Ligante Indutor de Apoptose Relacionado a TNF / Gelatina Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Biomaterials Ano de publicação: 2017 Tipo de documento: Article

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