Cell plasticity in epithelial homeostasis and tumorigenesis.
Nat Cell Biol
; 19(10): 1133-1141, 2017 Oct.
Article
em En
| MEDLINE
| ID: mdl-28945230
ABSTRACT
The adult organism is characterized by remarkable plasticity, which enables efficient regeneration and restoration of homeostasis after damage. When aberrantly activated, this plasticity contributes to tumour initiation and progression. Here we review recent advances in this field with a focus on cell fate changes and the epithelial-mesenchymal transition-two distinct, yet closely related, forms of plasticity with fundamental roles in homeostasis and cancer.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transformação Celular Neoplásica
/
Células Epiteliais
/
Plasticidade Celular
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Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Cell Biol
Ano de publicação:
2017
Tipo de documento:
Article