Efficacy of tocilizumab highlighted by FDG-PET/CT in a patient with relapsing polychondritis-associated aortitis.
Rheumatol Int
; 37(11): 1931-1935, 2017 Nov.
Article
em En
| MEDLINE
| ID: mdl-28965131
ABSTRACT
Relapsing polychondritis (RP) is a rare systemic inflammatory disease primarily affecting the ears, nose and tracheobronchial tree cartilage, but also the cardiovascular system. Cardiovascular complications are the second cause of mortality in RP. We report the case of a woman with a corticosteroid-resistant RP-associated aortitis, who was successfully treated with tocilizumab (TCZ). The FDG-PET/CT was a useful tool for diagnosing aortitis and assessing the effect of biotherapy. We conducted a systematic literature review confirming this is the first case of rapid and sustained remission in a patient with corticosteroid-resistant RP-associated aortitis after TCZ treatment administered as a first-line immunotherapy. However, further studies are needed to confirm the beneficial effect of TCZ used in this life-threatening condition.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aortite
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Policondrite Recidivante
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Fluordesoxiglucose F18
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Anticorpos Monoclonais Humanizados
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Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada
Tipo de estudo:
Risk_factors_studies
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Systematic_reviews
Limite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Rheumatol Int
Ano de publicação:
2017
Tipo de documento:
Article