Transfusion-associated hypoxemia in pediatric patients with solid tumors after autologous peripheral blood stem cell transplantation.
Transfus Apher Sci
; 56(5): 744-747, 2017 Oct.
Article
em En
| MEDLINE
| ID: mdl-28965826
ABSTRACT
BACKGROUND:
Although several types of transfusion-related adverse reactions (TRARs) have been reported, one of the most important involves respiratory features during and after blood transfusion. Transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO) are the most severe adverse events following blood transfusion, whereas transfusion-associated dyspneaã(TAD) is a less severe respiratory distress. However, there exists little evidence of these factors in pediatric populations. CASE REPORT Here, two cases of atypical TRARs with respiratory features, in pediatric patients with solid tumors, appearing after transfusion of platelet concentrate following autologous peripheral blood stem cell transplantation are reported. Both patients developed mild hypoxemia during PC transfusion, which continued for approximately 2 weeks. Chest radiography in either patient did not reveal any abnormalities that are included in the criteria of either TRALI or TACO. Both patients recovered following oxygen administration.CONCLUSION:
This complication of TRARs with respiratory features may occur more frequently in pediatric populations than realized because it may be under-recognized or under-reported. Accumulation of additional cases, including non-typical cases, is necessary to fully understand the pathology of TRARs, correctly classify these reactions, and improve care of patients receiving blood transfusions.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transfusão de Sangue Autóloga
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Reação Transfusional
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Neoplasias
Tipo de estudo:
Risk_factors_studies
Limite:
Child, preschool
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Humans
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Male
Idioma:
En
Revista:
Transfus Apher Sci
Ano de publicação:
2017
Tipo de documento:
Article