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Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity.
Arbez, Nicolas; Ratovitski, Tamara; Roby, Elaine; Chighladze, Ekaterine; Stewart, Jacqueline C; Ren, Mark; Wang, Xiaofang; Lavery, Daniel J; Ross, Christopher A.
Afiliação
  • Arbez N; From the Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, narbez1@jhmi.edu.
  • Ratovitski T; From the Division of Neurobiology, Department of Psychiatry and Behavioral Sciences.
  • Roby E; From the Division of Neurobiology, Department of Psychiatry and Behavioral Sciences.
  • Chighladze E; From the Division of Neurobiology, Department of Psychiatry and Behavioral Sciences.
  • Stewart JC; From the Division of Neurobiology, Department of Psychiatry and Behavioral Sciences.
  • Ren M; the Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, and.
  • Wang X; From the Division of Neurobiology, Department of Psychiatry and Behavioral Sciences.
  • Lavery DJ; the CHDI Foundation/CHDI Management Inc., Princeton, New Jersey 08540.
  • Ross CA; From the Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, caross@jhu.edu.
J Biol Chem ; 292(47): 19238-19249, 2017 11 24.
Article em En | MEDLINE | ID: mdl-28972180
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Processamento de Proteína Pós-Traducional / Doença de Huntington / Proteína Huntingtina / Mitocôndrias / Mutação / Neurônios Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Processamento de Proteína Pós-Traducional / Doença de Huntington / Proteína Huntingtina / Mitocôndrias / Mutação / Neurônios Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2017 Tipo de documento: Article