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Assessing DNA Methylation in Cancer Stem Cells.
Das, Sudipto; Moran, Bruce; Perry, Antoinette S.
Afiliação
  • Das S; Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Moran B; Cancer Biology and Therapeutics Laboratory, UCD Conway Institute of Biomedical and Biomolecular Research, University College Dublin, Belfield, Dublin 4, Ireland.
  • Perry AS; Cancer Biology and Therapeutics Laboratory, UCD Conway Institute of Biomedical and Biomolecular Research, University College Dublin, Belfield, Dublin 4, Ireland. antoinette.perry@ucd.ie.
Methods Mol Biol ; 1692: 157-178, 2018.
Article em En | MEDLINE | ID: mdl-28986896
ABSTRACT
Many cancer-associated epigenetic signatures are also commonly observed in stem cells, just as epigenetic stem cell patterns are in cancer cells. DNA methylation is recognized as a hallmark of cancer development and progression. Herein, we describe two approaches to analyze DNA methylation, which can be applied to study or discover DNA methylation aberrations throughout the genome, as well as a more targeted investigation of regions of interest in cancer stem cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas Limite: Humans Idioma: En Revista: Methods Mol Biol Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas Limite: Humans Idioma: En Revista: Methods Mol Biol Ano de publicação: 2018 Tipo de documento: Article