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Effect of statin on progression of symptomatic basilar artery stenosis and subsequent ischemic stroke.
Yum, Kyu Sun; Chang, Jun Young; Jeong, Won Joo; Lee, Sangkil; Jeong, Jin-Heon; Yeo, Min-Ju; Hong, Jeong-Ho; Park, Hong-Kyun; Chung, Inyoung; Kim, Beom Joon; Bang, Jae Seung; Bae, Hee-Joon; Han, Moon-Ku.
Afiliação
  • Yum KS; Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
  • Chang JY; Department of Neurology, Gyeongsang National University Changwon Hospital, Changwon, Korea.
  • Jeong WJ; Department of Critical Care, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Lee S; Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
  • Jeong JH; Department of Intensive Care Medicine and Neurology, Dong-A University Hospital, Busan, Korea.
  • Yeo MJ; Department of Neurology, Chungbuk National University Hospital, Chungju, Korea.
  • Hong JH; Department of Neurology, Keimyung University Dongsan Medical Center, Daegu, Korea.
  • Park HK; Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
  • Chung I; Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
  • Kim BJ; Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
  • Bang JS; Department of Neurosurgery, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Bae HJ; Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
  • Han MK; Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
PLoS One ; 12(10): e0183798, 2017.
Article em En | MEDLINE | ID: mdl-29020008
BACKGROUND AND OBJECTIVE: Symptomatic basilar artery stenosis (BAS) is associated with high risk of ischemic stroke recurrence. We aimed to investigate whether statin therapy might prevent the progression of symptomatic BAS and stroke recurrence. METHODS: We retrospectively analyzed the data of patients with acute ischemia with symptomatic BAS, which was assessed using magnetic resonance angiogram (MRA) imaging on admission day, and 1 year later (or the day of the clinical event). The clinical endpoints were recurrent ischemic stroke and its composites, transient ischemic attack, coronary disease, and vascular death. RESULTS: Of the 153 patients with symptomatic BAS, 114 (74.5%) were treated with a statin after experiencing a stroke. Statin therapy significantly prevented the progression of symptomatic BAS (7.0% vs 28.2%) and induced regression (22.8% vs 15.4%) compared to non-statin users (p = 0.002). There were 31 ischemic stroke incidences and 38 composite vascular events. Statin users showed significantly lower stroke recurrence (14.9% vs 35.9%, p = 0.05) and composite vascular events (17.5% vs 46.2%; odds ratio [OR], 0.29; 95% confidence interval [CI], 0.13-0.64) than those not using statins did. Recurrent stroke in the basilar territory and composite vascular events were more common in patients with progression of BAS than they were in other patients (OR, 5.16; 95% CI, 1.63-16.25 vs OR, 4.2; 95% CI, 1.56-11.34). CONCLUSION: Our study suggests that statin therapy may prevent the progression of symptomatic BAS and decrease the risk of subsequent ischemic stroke. Large randomized trials are needed to confirm this result.
Assuntos

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Insuficiência Vertebrobasilar / Isquemia Encefálica / Progressão da Doença / Inibidores de Hidroximetilglutaril-CoA Redutases / Acidente Vascular Cerebral Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En Revista: PLoS One Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Insuficiência Vertebrobasilar / Isquemia Encefálica / Progressão da Doença / Inibidores de Hidroximetilglutaril-CoA Redutases / Acidente Vascular Cerebral Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En Revista: PLoS One Ano de publicação: 2017 Tipo de documento: Article