Nedaplatin-Induced Arrhythmia: Retrospective Analysis of Three Cases.
J Coll Physicians Surg Pak
; 27(10): 657-659, 2017 Oct.
Article
em En
| MEDLINE
| ID: mdl-29056132
ABSTRACT
Nedaplatin (NDP) is a second-generation platinum derivative that was developed in Japan. Nowadays, it is being widely used in the management of lung cancer, esophageal cancer, head and neck cancers, especially when cisplatin and carboplatin cannot be tolerated or show drug resistance. To the best of our knowledge, there are few reported cases of NDP-induced bradycardia in the relevant medical literature. The current report presents three patients treated with NDP chemotherapy-induced serious arrhythmias. The three cases developed sinus tachycardia and atrial premature beats, complete left bundle branch block, and bigeminy ventricular premature contraction, in the second, sixth and second cycle, respectively. No one died of cardiac toxicity. These were treated with dexamethasone, 5 mg intravenous injection and diphenhydramine 20 mg, intramuscular injection. The heart rhythm returned to normal in 30 minutes, a day, and four days, respectively.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organoplatínicos
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Arritmias Cardíacas
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Dexametasona
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Frequência Cardíaca
Limite:
Aged
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Coll Physicians Surg Pak
Ano de publicação:
2017
Tipo de documento:
Article