Your browser doesn't support javascript.
loading
Danshen (Salvia miltiorrhiza) protects ovariectomized rats fed with high-saturated fat-sucrose diet from bone loss.
Dong, X L; Yu, W X; Li, C M; He, S; Zhou, L P; Poon, C W; Wong, M S.
Afiliação
  • Dong XL; State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, People's Republic of China.
  • Yu WX; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Y806, Hung Hom, Kowloon, Hong Kong, People's Republic of China.
  • Li CM; State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, People's Republic of China.
  • He S; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Y806, Hung Hom, Kowloon, Hong Kong, People's Republic of China.
  • Zhou LP; State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, People's Republic of China.
  • Poon CW; Department of Biochemistry and Molecular Biology, Guangdong Pharmaceutical College, Guangzhou, People's Republic of China.
  • Wong MS; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Y806, Hung Hom, Kowloon, Hong Kong, People's Republic of China.
Osteoporos Int ; 29(1): 223-235, 2018 01.
Article em En | MEDLINE | ID: mdl-29058051
Dietary patterns may interfere with the efficacy of herbal intervention. Our results demonstrated the protective effects of Salvia miltiorrhiza aqueous extract (SMA) on bone metabolism were influenced by levels of dietary fat and sucrose in ovariectomized (OVX) rats through its actions on attenuating lipid deposition and oxidative stress in rats. INTRODUCTION: Salvia miltiorrhiza (SM), also known as Danshen, has been tested as an osteoporosis treatment in a series of small, short human trials that generally report improvements in bone property. However, dietary patterns may interfere with the effects of herbal intervention. We hypothesized that dietary fat and sucrose levels could influence the effects of SM supplementation on bone in estrogen-deficient animals. METHODS: Six-month-old Sprague-Dawley sham or OVX rats were fed either a low-saturated fat-sucrose (LFS, a diet that was similar in composition to normal rat chow) or a high-fat-sucrose (HFS) diet and OVX rats were treated (8 rats/group) with SM aqueous extract (SMA, 600 mg/kg/day), 17ß-estradiol (1 mg/kg/day), or vehicle for 12 weeks. RESULTS: SMA significantly improved bone properties as revealed by the increase in trabecular bone mineral density and decrease in trabecular separation at proximal metaphysis of the tibia (PT) in HFS-fed OVX rats, but not in LFS-fed OVX rats. SMA greatly reduced lipid deposition and malondialdehyde levels, improved the activities of superoxide dismutase, catalase, and glutathione peroxidase in the livers of HFS-fed OVX rats. SMA could directly improve the proliferation and differentiation in vitro in an H2O2-induced preosteoblast cell model by attenuating cellular reactive oxygen species levels. CONCLUSIONS: The protective effects of SMA on bone metabolism were influenced by dietary fat and sucrose levels in OVX rats. The ability of SMA to reduce bone loss in HFS-fed OVX rats was associated with the attenuation of lipid deposition and oxidative stress levels.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Gorduras na Dieta / Osteoporose Pós-Menopausa / Sacarose Alimentar / Dieta Hiperlipídica / Fitoterapia Limite: Animals / Female / Humans Idioma: En Revista: Osteoporos Int Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Gorduras na Dieta / Osteoporose Pós-Menopausa / Sacarose Alimentar / Dieta Hiperlipídica / Fitoterapia Limite: Animals / Female / Humans Idioma: En Revista: Osteoporos Int Ano de publicação: 2018 Tipo de documento: Article