Establishment of a platform for molecular and immunological characterization of the RNA-dependent-RNA-polymerase NS5B of an Egyptian HCV isolate.

Gewaid, Hossam; Mesalam, Ahmed A; Ibrahim, Ahmed A; Abdel Shafy, Dina N; Abdel Shafy, Rola N; Emara, Nahed; Hamdy, Soha M; Gewaid, Mohy; Bahgat, Mahmoud M

Gewaid, Hossam; Mesalam, Ahmed A; Ibrahim, Ahmed A; Abdel Shafy, Dina N; Abdel Shafy, Rola N; Emara, Nahed; Hamdy, Soha M; Gewaid, Mohy; Bahgat, Mahmoud M.

Afiliação

Gewaid H; Research Group Immune- and Bio-markers for Infection, the Center of Excellence for Advanced Sciences, the National Research Center, Cairo, Egypt.
Mesalam AA; Therapeutic Chemistry Department, the National Research Center, Cairo, Egypt.
Ibrahim AA; Research Group Immune- and Bio-markers for Infection, the Center of Excellence for Advanced Sciences, the National Research Center, Cairo, Egypt.
Abdel Shafy DN; Therapeutic Chemistry Department, the National Research Center, Cairo, Egypt.
Abdel Shafy RN; Research Group Immune- and Bio-markers for Infection, the Center of Excellence for Advanced Sciences, the National Research Center, Cairo, Egypt.
Emara N; Therapeutic Chemistry Department, the National Research Center, Cairo, Egypt.
Hamdy SM; Research Group Immune- and Bio-markers for Infection, the Center of Excellence for Advanced Sciences, the National Research Center, Cairo, Egypt.
Gewaid M; Water Pollution Research Department, the National Research Center, Cairo, Egypt.
Bahgat MM; Research Group Immune- and Bio-markers for Infection, the Center of Excellence for Advanced Sciences, the National Research Center, Cairo, Egypt.

J Med Virol ; 90(3): 545-558, 2018 03.

Article em En | MEDLINE | ID: mdl-29064582

Assuntos

Hepacivirus/enzimologia; Hepacivirus/genética; RNA Polimerase Dependente de RNA/genética; Proteínas não Estruturais Virais/genética; Animais; Clonagem Molecular; Egito; Feminino; Genótipo; Células Hep G2; Hepatite C/virologia; Humanos; Imunização; Camundongos; Camundongos Endogâmicos BALB C; Modelos Moleculares; Mutação; Filogenia; Regiões Promotoras Genéticas; RNA Polimerase Dependente de RNA/imunologia; Alinhamento de Sequência; Análise de Sequência de DNA; Proteínas não Estruturais Virais/imunologia

Palavras-chave

3D model; HCV-4a-NS5B; diagnostic value; mammalian expression; phylogeny; sequence analysis

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 4_TD Base de dados: MEDLINE Assunto principal: RNA Polimerase Dependente de RNA / Proteínas não Estruturais Virais / Hepacivirus Limite: Animals / Female / Humans País/Região como assunto: Africa Idioma: En Revista: J Med Virol Ano de publicação: 2018 Tipo de documento: Article

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