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Seco-dammarane triterpenoids from the leaves of Cyclocarya paliurus.
Chen, Yan-Jiao; Na, Liang; Fan, Jialong; Zhao, Jianping; Hussain, Nusrat; Jian, Yu-Qing; Yuan, Hanwen; Li, Bin; Liu, Bin; Choudhary, M Iqbal; Khan, Ikhlas; Wang, Wei.
Afiliação
  • Chen YJ; TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Pakistan TCM and Ethnomedicine Research Center, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, People's Republic of China.
  • Na L; TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Pakistan TCM and Ethnomedicine Research Center, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, People's Republic of China; College of Traditional Chinese Medicine, Hunan Food and Drug Vocational College,
  • Fan J; College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, Hunan University, Changsha, 410082, People's Republic of China.
  • Zhao J; National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, MS 38677, USA.
  • Hussain N; TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Pakistan TCM and Ethnomedicine Research Center, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, People's Republic of China; H.E.J. Research Institute of Chemistry, International Center for Chemical and Bi
  • Jian YQ; TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Pakistan TCM and Ethnomedicine Research Center, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, People's Republic of China.
  • Yuan H; TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Pakistan TCM and Ethnomedicine Research Center, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, People's Republic of China.
  • Li B; TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Pakistan TCM and Ethnomedicine Research Center, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, People's Republic of China.
  • Liu B; College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, Hunan University, Changsha, 410082, People's Republic of China. Electronic address: binliu2001@hotmail.com.
  • Choudhary MI; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
  • Khan I; National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, MS 38677, USA.
  • Wang W; TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Pakistan TCM and Ethnomedicine Research Center, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, People's Republic of China. Electronic address: wangwei402@hotmail.com.
Phytochemistry ; 145: 85-92, 2018 Jan.
Article em En | MEDLINE | ID: mdl-29107810
ABSTRACT
The leaves of Cyclocarya paliurus with sweet taste are often used as herbal tea in People's Republic of China. In this study eight previously undescribed seco-dammarane type triterpenoids, cyclocariols A-H along with seven known compounds were isolated and characterized from its leaves. A possible biogenetic pathway for seco-dammarane type triterpenoids formation has been discussed. Cyclocariols A-H were evaluated for their cytotoxicities against human liver (SMMC-7721) and breast cancer (BT-549) cell lines. Cyclocariols A, B, E, and H were also tested against human colon tumor (HCT-116) cell lines, where all four exhibited good activities with IC50 values of 6.53, 4.94, 8.24, and 6.48 µM, respectively.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Folhas de Planta / Juglandaceae / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Revista: Phytochemistry Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Folhas de Planta / Juglandaceae / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Revista: Phytochemistry Ano de publicação: 2018 Tipo de documento: Article