Post-irradiation morphoea of the breast: a case report and review of the literature.
Histopathology
; 72(2): 342-350, 2018 Jan.
Article
em En
| MEDLINE
| ID: mdl-29110314
ABSTRACT
We describe a 44-year-old female with triple-negative breast cancer who developed skin erythaema, sclerosis and contracture of her entire right breast 15 months after completion of post-lumpectomy chemotherapy and radiotherapy, consistent with post-irradiation morphoea (PIM). PIM is a rare complication of breast irradiation that impairs a patient's quality of life. PIM is located usually at the radiation port or in the surrounding tissue. Clinically, PIM is misdiagnosed commonly as lymphoedema and cellulitis in the early inflammatory phase, and recurrent breast cancer, chronic radiodermatitis (CRD), radiation-induced fibrosis (RIF), post-irradiation pseudosclerodermatous panniculitis (PIPP), atypical vascular lesions (AVL) or angiosarcoma (AS) in the late burnout phase. Arriving at the correct diagnosis typically requires a multidisciplinary approach, including a skin biopsy for confirmation. To date, satisfactory treatment of this condition has been challenging. and the clinical outcome after therapy is often unsatisfactory.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lesões por Radiação
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Esclerodermia Localizada
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Neoplasias de Mama Triplo Negativas
Aspecto:
Patient_preference
Limite:
Adult
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Female
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Humans
Idioma:
En
Revista:
Histopathology
Ano de publicação:
2018
Tipo de documento:
Article