Circulating fetal and total cell-free DNA, and sHLA-G in black South African women with gestational hypertension and pre-eclampsia.
Hypertens Pregnancy
; 36(4): 295-301, 2017 Nov.
Article
em En
| MEDLINE
| ID: mdl-29115889
ABSTRACT
OBJECTIVE:
Quantification of circulating fetal and total cell-free DNA (cfDNA) and soluble human leucocyte antigen (HLAG) in gestational hypertension and pre-eclampsia.METHODS:
Serum cfDNA were quantified in controls, pre-eclamptics, and gestational hypertensive patients using real-time qPCR. Soluble HLAG was measured by enzyme-linked immune-sorbent assay.RESULTS:
Serum fetal and total cfDNA levels were higher in pre-eclampsia compared with the controls and gestational hypertensives (p < 0.001), more so in severe compared with mild-to-moderate pre-eclampsia (p < 0.05). Soluble HLAG levels were lower in pre-eclamptics than controls and gestational hypertension (p < 0.05).CONCLUSION:
Circulating fetal and total cfDNA were increased, while soluble HLAG was decreased in pre-eclampsia.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
/
Hipertensão Induzida pela Gravidez
/
Antígenos HLA-G
/
Ácidos Nucleicos Livres
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
País/Região como assunto:
Africa
Idioma:
En
Revista:
Hypertens Pregnancy
Ano de publicação:
2017
Tipo de documento:
Article