Birth, coming of age and death: The intriguing life of long noncoding RNAs.

Castelo-Branco, Gonçalo; Bonetti, Alessandro

Castelo-Branco, Gonçalo; Bonetti, Alessandro.

Afiliação

Samudyata; Laboratory of Molecular Neurobiology, Department Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Castelo-Branco G; Laboratory of Molecular Neurobiology, Department Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Bonetti A; Laboratory of Molecular Neurobiology, Department Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, RIKEN Yokohama, Japan. Electronic address: alessandro.bonetti@ki.se.

Semin Cell Dev Biol ; 79: 143-152, 2018 07.

Article em En | MEDLINE | ID: mdl-29133230

ABSTRACT

ABSTRACT

Mammalian genomes are pervasively transcribed, with long noncoding RNAs being the most abundant fraction. Recent studies have highlighted the central role played by these transcripts in several physiological and pathological processes. Despite several metabolic features shared between coding and noncoding transcripts, these two classes of RNAs exhibit multiple differences regarding their biogenesis and processing. Here we review such distinctions, focusing on the unique features of specific long noncoding RNAs.

Assuntos

Genoma/genética; Precursores de RNA/genética; Processamento Pós-Transcricional do RNA; RNA Longo não Codificante/genética; Animais; Regulação da Expressão Gênica; Humanos; Modelos Genéticos; Estabilidade de RNA; RNA Longo não Codificante/metabolismo

Palavras-chave

Polyadenylation; RNA processing; Splicing; Subcellular localization; Transcription; circRNA; eRNA; lncRNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Precursores de RNA / Processamento Pós-Transcricional do RNA / Genoma / RNA Longo não Codificante Limite: Animals / Humans Idioma: En Revista: Semin Cell Dev Biol Ano de publicação: 2018 Tipo de documento: Article

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