Importance of Rigidity in Designing Small Molecule Drugs To Tackle Protein-Protein Interactions (PPIs) through Stabilization of Desired Conformers.
J Med Chem
; 61(10): 4283-4289, 2018 05 24.
Article
em En
| MEDLINE
| ID: mdl-29140691
ABSTRACT
Tackling PPIs, particularly by stabilizing clinically favored conformations of target proteins, with orally available, bona fide small molecules remains a significant but immensely worthwhile challenge for the pharmaceutical industry. Success may be more likely through the application of nature's learnings to build intrinsic rigidity into the design of clinical candidates.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Desenho de Fármacos
/
Proteínas
/
Bibliotecas de Moléculas Pequenas
/
Domínios e Motivos de Interação entre Proteínas
/
Estabilidade Proteica
Limite:
Humans
Idioma:
En
Revista:
J Med Chem
Ano de publicação:
2018
Tipo de documento:
Article