NAD<sup>+</sup> -Dependent Dehydrogenase PctP and Pyridoxal 5'-Phosphate Dependent Aminotransferase PctC Catalyze the First Postglycosylation Modification of the Sugar Intermediate in Pactamycin Biosynthesis.

Hirayama, Akane; Chu, Jinmiao; Goto, Ena; Kudo, Fumitaka; Eguchi, Tadashi

NAD⁺ -Dependent Dehydrogenase PctP and Pyridoxal 5'-Phosphate Dependent Aminotransferase PctC Catalyze the First Postglycosylation Modification of the Sugar Intermediate in Pactamycin Biosynthesis.

Hirayama, Akane; Chu, Jinmiao; Goto, Ena; Kudo, Fumitaka; Eguchi, Tadashi.

Afiliação

Hirayama A; Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo, 152-8551, Japan.
Chu J; Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo, 152-8551, Japan.
Goto E; Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo, 152-8551, Japan.
Kudo F; Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo, 152-8551, Japan.
Eguchi T; Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo, 152-8551, Japan.

Chembiochem ; 19(2): 126-130, 2018 01 18.

Article em En | MEDLINE | ID: mdl-29148266

Assuntos

Biocatálise; Oxirredutases/metabolismo; Pactamicina/biossíntese; Açúcares/metabolismo; Transaminases/metabolismo; Glicosilação; Pactamicina/química; Streptomyces/enzimologia; Açúcares/química

Palavras-chave

aminocyclitols; biosynthesis; enzymes; natural products; pactamycin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxirredutases / Pactamicina / Açúcares / Biocatálise / Transaminases Idioma: En Revista: Chembiochem Ano de publicação: 2018 Tipo de documento: Article

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