Design, Synthesis, and Evaluation of &#969;-(Isothiocyanato)alkylphosphinates and Phosphine Oxides as Antiproliferative Agents.

Janczewski, Lukasz; Psurski, Mateusz; Switalska, Marta; Gajda, Anna; Goszczynski, Tomasz M; Oleksyszyn, Józef; Wietrzyk, Joanna; Gajda, Tadeusz

Design, Synthesis, and Evaluation of ω-(Isothiocyanato)alkylphosphinates and Phosphine Oxides as Antiproliferative Agents.

Janczewski, Lukasz; Psurski, Mateusz; Switalska, Marta; Gajda, Anna; Goszczynski, Tomasz M; Oleksyszyn, Józef; Wietrzyk, Joanna; Gajda, Tadeusz.

Afiliação

Janczewski L; Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924, Lódz, Poland.
Psurski M; Department of Experimental Oncology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114, Wroclaw, Poland.
Switalska M; Department of Experimental Oncology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114, Wroclaw, Poland.
Gajda A; Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924, Lódz, Poland.
Goszczynski TM; Department of Experimental Oncology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114, Wroclaw, Poland.
Oleksyszyn J; Division of Medicinal Chemistry and Microbiology, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370, Wroclaw, Poland.
Wietrzyk J; Department of Experimental Oncology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114, Wroclaw, Poland.
Gajda T; Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924, Lódz, Poland.

ChemMedChem ; 13(1): 105-115, 2018 01 08.

Article em En | MEDLINE | ID: mdl-29171934

Assuntos

Antineoplásicos/síntese química; Desenho de Fármacos; Fosfinas/química; Ácidos Fosfínicos/química; Animais; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Apoptose/efeitos dos fármacos; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Feminino; Humanos; Isotiocianatos/química; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Camundongos; Camundongos Endogâmicos BALB C; Neoplasias/tratamento farmacológico; Neoplasias/patologia; Óxidos/química; Fosfinas/farmacologia; Fosfinas/uso terapêutico; Ácidos Fosfínicos/farmacologia; Ácidos Fosfínicos/uso terapêutico; Relação Estrutura-Atividade

Palavras-chave

apoptosis; cell cycle; isothiocyanates; isothiocyanatoalkyl phosphinates; isothiocyanatoalkyl phosphine oxides

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfinas / Ácidos Fosfínicos / Desenho de Fármacos / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: ChemMedChem Ano de publicação: 2018 Tipo de documento: Article

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