Safe-by-Design Ligand-Coated ZnO Nanocrystals Engineered by an Organometallic Approach: Unique Physicochemical Properties and Low Toxicity toward Lung Cells.
Chemistry
; 24(16): 4033-4042, 2018 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-29178547
ABSTRACT
The unique physicochemical properties and biocompatibility of zinc oxide nanocrystals (ZnO NCs) are strongly dependent on the nanocrystal/ligand interface, which is largely determined by synthetic procedures. Stable ZnO NCs coated with a densely packed shell of 2-(2-methoxyethoxy)acetate ligands, which act as miniPEG prototypes, with average core size and hydrodynamic diameter of 4-5 and about 12â
nm, respectively, were prepared by an organometallic self-supporting approach, fully characterized, and used as a model system for biological studies. The ZnO NCs from the one-pot, self-supporting organometallic procedure exhibit unique physicochemical properties such as relatively high quantum yield (up to 28 %), ultralong photoluminescence decay (up to 2.1â
µs), and EPR silence under standard conditions. The cytotoxicity of the resulting ZnO NCs toward normal (MRC-5) and cancer (A549) human lung cell lines was tested by MTT assay, which demonstrated that these brightly luminescent, quantum-sized ZnO NCs have a low negative impact on mammalian cell lines. These results substantiate that the self-supporting organometallic approach is a highly promising method to obtain high-quality, nontoxic, ligand-coated ZnO NCs with prospective biomedical applications.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Óxido de Zinco
/
Nanopartículas Metálicas
Tipo de estudo:
Observational_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Chemistry
Ano de publicação:
2018
Tipo de documento:
Article