Thrombolytic fucoidans inhibit the tPA-PAI1 complex, indicating activation of plasma tissue-type plasminogen activator is a mechanism of fucoidan-mediated thrombolysis in a mouse thrombosis model.

Choi, Younshick; Min, Soon-Ki; Usoltseva, Roza; Silchenko, Artem; Zvyagintseva, Tatyana; Ermakova, Svetlana; Kim, Jong-Ki

Choi, Younshick; Min, Soon-Ki; Usoltseva, Roza; Silchenko, Artem; Zvyagintseva, Tatyana; Ermakova, Svetlana; Kim, Jong-Ki.

Afiliação

Choi Y; Department of Radiology and Biomedical Engineering, School of Medicine, Catholic University of Daegu, Republic of Korea.
Min SK; Department of Radiology and Biomedical Engineering, School of Medicine, Catholic University of Daegu, Republic of Korea.
Usoltseva R; Department of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch, Russian Academy of Sciences, Russia.
Silchenko A; Department of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch, Russian Academy of Sciences, Russia.
Zvyagintseva T; Department of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch, Russian Academy of Sciences, Russia.
Ermakova S; Department of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch, Russian Academy of Sciences, Russia. Electronic address: swetlana_e@mail.ru.
Kim JK; Department of Radiology and Biomedical Engineering, School of Medicine, Catholic University of Daegu, Republic of Korea. Electronic address: jkkim@cu.ac.kr.

Thromb Res ; 161: 22-25, 2018 01.

Article em En | MEDLINE | ID: mdl-29178986

Assuntos

Fibrinólise/efeitos dos fármacos; Polissacarídeos/farmacologia; Serpina E2/antagonistas & inibidores; Trombose/tratamento farmacológico; Ativador de Plasminogênio Tecidual/antagonistas & inibidores; Animais; Modelos Animais de Doenças; Camundongos; Camundongos Endogâmicos BALB C; Serpina E2/metabolismo; Trombose/sangue; Ativador de Plasminogênio Tecidual/metabolismo; Ativador de Plasminogênio Tecidual/farmacologia

Palavras-chave

Activating free tPA; Fucoidan; PAI-1 binding; Reperfusion; Thrombolysis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polissacarídeos / Trombose / Ativador de Plasminogênio Tecidual / Serpina E2 / Fibrinólise Limite: Animals Idioma: En Revista: Thromb Res Ano de publicação: 2018 Tipo de documento: Article

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