Rational incorporation of molecular adjuvants into a hybrid nanoparticle-based nicotine vaccine for immunotherapy against nicotine addiction.

Zhao, Zongmin; Harris, Brian; Hu, Yun; Harmon, Theresa; Pentel, Paul R; Ehrich, Marion; Zhang, Chenming

Zhao, Zongmin; Harris, Brian; Hu, Yun; Harmon, Theresa; Pentel, Paul R; Ehrich, Marion; Zhang, Chenming.

Afiliação

Zhao Z; Department of Biological Systems Engineering, Virginia Tech, Blacksburg, VA 24061, USA.
Harris B; Department of Biological Systems Engineering, Virginia Tech, Blacksburg, VA 24061, USA.
Hu Y; Department of Biological Systems Engineering, Virginia Tech, Blacksburg, VA 24061, USA.
Harmon T; Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA.
Pentel PR; Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA.
Ehrich M; Department of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, VA 24061, USA.
Zhang C; Department of Biological Systems Engineering, Virginia Tech, Blacksburg, VA 24061, USA. Electronic address: chzhang2@vt.edu.

Biomaterials ; 155: 165-175, 2018 Feb.

Article em En | MEDLINE | ID: mdl-29179132

Assuntos

Nanopartículas/química; Nicotina/química; Tabagismo/prevenção & controle; Vacinas/sangue; Adjuvantes Imunológicos/química; Animais; Imidazóis/química; Imunoterapia; Lipídeo A/análogos & derivados; Lipídeo A/química; Camundongos; Oligodesoxirribonucleotídeos/química

Palavras-chave

Anti-nicotine antibody; Hybrid nanoparticle; Molecular adjuvant; Nicotine addiction; Nicotine vaccine; Toll-like receptors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tabagismo / Vacinas / Nanopartículas / Nicotina Limite: Animals Idioma: En Revista: Biomaterials Ano de publicação: 2018 Tipo de documento: Article

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