Learning from regeneration research organisms: The circuitous road to scar free wound healing.
Dev Biol
; 433(2): 144-154, 2018 01 15.
Article
em En
| MEDLINE
| ID: mdl-29179946
ABSTRACT
The skin is the largest organ in the body and plays multiple essential roles ranging from regulating temperature, preventing infection and ultimately defining who we are physically. It is a highly dynamic organ that constantly replaces the outermost cells throughout life. However, when faced with a major injury, human skin cannot restore a significant lesion to its original functionality, instead a reparative scar is formed. In contrast to this, many other species have the unique ability to regenerate full thickness skin without formation of scar tissue. Here we review recent advances in the field that shed light on how the skin cells in regenerative species react to injury to prevent scar formation versus scar forming humans.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cicatrização
/
Cicatriz
/
Modelos Animais
Limite:
Animals
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Humans
Idioma:
En
Revista:
Dev Biol
Ano de publicação:
2018
Tipo de documento:
Article