The PARP-1 inhibitor Olaparib suppresses BRCA1 protein levels, increases apoptosis and causes radiation hypersensitivity in BRCA1<sup>+/-</sup> lymphoblastoid cells.

Bourton, Emma C; Ahorner, Pia-Amata; Plowman, Piers N; Zahir, Sheba Adam; Al-Ali, Hussein; Parris, Christopher N

The PARP-1 inhibitor Olaparib suppresses BRCA1 protein levels, increases apoptosis and causes radiation hypersensitivity in BRCA1^+/- lymphoblastoid cells.

Bourton, Emma C; Ahorner, Pia-Amata; Plowman, Piers N; Zahir, Sheba Adam; Al-Ali, Hussein; Parris, Christopher N.

Afiliação

Bourton EC; Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University, Uxbridge Middlesex, UB8 3PH, UK.
Ahorner PA; Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University, Uxbridge Middlesex, UB8 3PH, UK.
Plowman PN; Department of Radiotherapy, St. Bartholomew's Hospital, West Smithfield, London, EC1A 7BE, UK.
Zahir SA; Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University, Uxbridge Middlesex, UB8 3PH, UK.
Al-Ali H; Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University, Uxbridge Middlesex, UB8 3PH, UK.
Parris CN; Department of Biomedical and Forensic Science, Faculty of Science and Technology, Anglia Ruskin University, East Road Cambridge, Cambridgeshire, CB1 1PT, UK.

J Cancer ; 8(19): 4048-4056, 2017.

Article em En | MEDLINE | ID: mdl-29187880

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies Idioma: En Revista: J Cancer Ano de publicação: 2017 Tipo de documento: Article

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