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An immune-molecular hypothesis supporting infectious aetiopathogenesis of Kawasaki disease in children.
Capittini, Cristina; Emmi, Giacomo; Mannarino, Savina; Bossi, Grazia; Dellepiane, Rosa Maria; Salice, Patrizia; Pietrogrande, Maria Cristina; Pasi, Annamaria; De Silvestri, Annalisa; Tinelli, Carmine; Martinetti, Miryam.
Afiliação
  • Capittini C; Biometry and Clinical Epidemiology, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
  • Emmi G; Department of Experimental and Clinical Medicine, University of Firenze, Italy.
  • Mannarino S; Department of Pediatrics, Pediatric Cardiology, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
  • Bossi G; Department of Pediatrics, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
  • Dellepiane RM; Pediatric Clinic II, University of Milan, IRCCS Ca' Granda Foundation, Ospedale Maggiore Policlinico, Milan, Italy.
  • Salice P; Pediatric Cardiology, Cardiology Unit, IRCCS Ca' Granda Foundation, Ospedale Maggiore Policlinico, Milan, Italy.
  • Pietrogrande MC; Pediatric Clinic II, University of Milan, IRCCS Ca' Granda Foundation, Ospedale Maggiore Policlinico, Milan, Italy.
  • Pasi A; Immunohematology and Transfusion Center, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
  • De Silvestri A; Biometry and Clinical Epidemiology, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
  • Tinelli C; Biometry and Clinical Epidemiology, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
  • Martinetti M; Immunohematology and Transfusion Center, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
Eur J Immunol ; 48(3): 543-545, 2018 03.
Article em En | MEDLINE | ID: mdl-29193035
ABSTRACT
The competitive binding between CpG-ODN (single-stranded DNA from pathogens) and HLA-B and HLA-A ligands for the inhibitory Killer Immunoglobulin-like Receptors (KIR)3DL1/2 may lead to possible hypo-sensing of pathogens and ineffective clearance. We observed an overabundance of HLA ligands for inhibitory KIR with three domains in KD subjects.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Modelos Imunológicos / Síndrome de Linfonodos Mucocutâneos Limite: Child / Humans Idioma: En Revista: Eur J Immunol Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Modelos Imunológicos / Síndrome de Linfonodos Mucocutâneos Limite: Child / Humans Idioma: En Revista: Eur J Immunol Ano de publicação: 2018 Tipo de documento: Article