Synthesis and biological evaluation of 1-amino isochromans from 2-bromoethyl benzaldehyde and amines in acid medium.
Bioorg Med Chem Lett
; 28(2): 196-201, 2018 01 15.
Article
em En
| MEDLINE
| ID: mdl-29198904
ABSTRACT
We have developed a facile and efficient synthetic route to substituted isochromans for the first time by reacting 2-(2-bromoethyl)benzaldehyde with a variety of aryl, heteroaryl amines in AcOH. The reaction is catalyst/additive free and takes place at reflux conditions with short reaction time to furnish products in good to excellent yields. All the compounds have been characterized by spectral techniques such as IR, 1H NMR and Mass etc. Synthesized compounds were evaluated for antimicrobial activity against specific bacterial like 1) Staphylococcus strains aureus 2) Bacillus subtilis 3) Escherichia coli 4) Pseudomonas aeruginosa. Compounds 3e, 3n, 3â¯m, 3â¯l, 3â¯k, 3j and 3b showed most potent in vitro activity against bacterial strains.
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Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Benzaldeídos
/
Cromanos
/
Ácido Acético
/
Aminas
/
Antibacterianos
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2018
Tipo de documento:
Article