The amino analogue of ß-boswellic acid efficiently attenuates the release of pro-inflammatory mediators than its parent compound through the suppression of NF-&#954;B/I&#954;B&#945; signalling axis.

Gupta, Shilpa; Ahsan, Aitizaz Ul; Wani, Abubakar; Khajuria, Vidushi; Nazir, Lone A; Sharma, Simmi; Bhagat, Asha; Raj Sharma, Parduman; Bhardwaj, Subhash; Peerzada, Kaiser J; Ali Shah, Bhahwal; Ahmed, Zabeer

The amino analogue of ß-boswellic acid efficiently attenuates the release of pro-inflammatory mediators than its parent compound through the suppression of NF-κB/IκBα signalling axis.

Gupta, Shilpa; Ahsan, Aitizaz Ul; Wani, Abubakar; Khajuria, Vidushi; Nazir, Lone A; Sharma, Simmi; Bhagat, Asha; Raj Sharma, Parduman; Bhardwaj, Subhash; Peerzada, Kaiser J; Ali Shah, Bhahwal; Ahmed, Zabeer.

Afiliação

Gupta S; Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicines, India; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicines, India.
Ahsan AU; Cytogenetics Lab, Department of Zoology, Panjab University, Chandigarh, India.
Wani A; Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicines, India; CancerPharmacology Division, CSIR-Indian Institute of Integrative Medicines, India.
Khajuria V; Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicines, India; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicines, India.
Nazir LA; Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicines, India; PK-PD and Toxicology Division, CSIR-Indian Institute of Integrative Medicine, India.
Sharma S; Natural Product Microbes, CSIR-Indian Institute of Integrative Medicines, India.
Bhagat A; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicines, India.
Raj Sharma P; CancerPharmacology Division, CSIR-Indian Institute of Integrative Medicines, India.
Bhardwaj S; Department of Pathology, Government Medical College Jammu, India.
Peerzada KJ; PK-PD and Toxicology Division, CSIR-Indian Institute of Integrative Medicine, India.
Ali Shah B; Natural Product Microbes, CSIR-Indian Institute of Integrative Medicines, India.
Ahmed Z; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicines, India. Electronic address: zahmed@iiim.ac.in.

Cytokine ; 107: 93-104, 2018 07.

Article em En | MEDLINE | ID: mdl-29229421

Assuntos

Mediadores da Inflamação/metabolismo; Inflamação/tratamento farmacológico; Inibidor de NF-kappaB alfa/metabolismo; NF-kappa B/metabolismo; Transdução de Sinais/efeitos dos fármacos; Triterpenos/farmacologia; Animais; Anti-Inflamatórios/farmacologia; Linhagem Celular; Ciclo-Oxigenase 2/metabolismo; Citocinas/metabolismo; Edema/tratamento farmacológico; Edema/metabolismo; Inflamação/metabolismo; Camundongos; Camundongos Endogâmicos BALB C; Óxido Nítrico Sintase Tipo II/metabolismo; Células RAW 264.7; Regulação para Cima/efeitos dos fármacos

Palavras-chave

3-α-o-acetoxy-4ß-amino-11-oxo-24-norurs-12-ene (BA-25); Cyclooxygenase-2; Lipopolysaccharide; Mouse paw oedema; Nitric oxide; ß-Boswellic acid (BA)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Transdução de Sinais / NF-kappa B / Mediadores da Inflamação / Inibidor de NF-kappaB alfa / Inflamação Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Cytokine Ano de publicação: 2018 Tipo de documento: Article

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