Your browser doesn't support javascript.
loading
Cost-effectiveness of cell-free DNA in maternal blood testing for prenatal detection of trisomy 21, 18 and 13: a systematic review.
García-Pérez, Lidia; Linertová, Renata; Álvarez-de-la-Rosa, Margarita; Bayón, Juan Carlos; Imaz-Iglesia, Iñaki; Ferrer-Rodríguez, Jorge; Serrano-Aguilar, Pedro.
Afiliação
  • García-Pérez L; Servicio de Evaluación, Servicio Canario de la Salud, Camino Candelaria Nº 44, 1ª planta, El Rosario, 38109, Santa Cruz De Tenerife, Canary Islands, Spain. lidia.garciaperez@sescs.es.
  • Linertová R; Fundación Canaria de Investigación Sanitaria (FUNCANIS), Camino Candelaria Nº 44, 1ª planta, El Rosario, 38109, Santa Cruz De Tenerife, Canary Islands, Spain. lidia.garciaperez@sescs.es.
  • Álvarez-de-la-Rosa M; Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Madrid, Spain. lidia.garciaperez@sescs.es.
  • Bayón JC; Centro de Investigaciones Biomédicas de Canarias (CIBICAN), Universidad de La Laguna, La Laguna, Spain. lidia.garciaperez@sescs.es.
  • Imaz-Iglesia I; Facultad de Ciencias Económicas y Empresariales, Universidad de La Laguna, Campus de Guajara, Camino de la Hornera s/n, La Laguna, 38071, Santa Cruz De Tenerife, Spain. lidia.garciaperez@sescs.es.
  • Ferrer-Rodríguez J; Servicio de Evaluación, Servicio Canario de la Salud, Camino Candelaria Nº 44, 1ª planta, El Rosario, 38109, Santa Cruz De Tenerife, Canary Islands, Spain.
  • Serrano-Aguilar P; Fundación Canaria de Investigación Sanitaria (FUNCANIS), Camino Candelaria Nº 44, 1ª planta, El Rosario, 38109, Santa Cruz De Tenerife, Canary Islands, Spain.
Eur J Health Econ ; 19(7): 979-991, 2018 Sep.
Article em En | MEDLINE | ID: mdl-29249015
The aim of this paper was to conduct a systematic review of the cost-effectiveness of the analysis of cell-free DNA in maternal blood, often called the non-invasive prenatal test (NIPT), in the prenatal screening of trisomy in chromosomes 21, 18 and 13. MEDLINE, MEDLINE in process, EMBASE, and Cochrane Library were searched in April 2017. We selected: (1) economic evaluations that estimated the costs and detected cases of trisomy 21, 18 or 13; (2) comparisons of prenatal screening with NIPT (universal or contingent strategies) and the usual screening without NIPT, (3) in pregnant women with any risk of foetal anomalies. Studies were reviewed by two researchers. Data were extracted, the methodological quality was assessed and a narrative synthesis was prepared. In total, 12 studies were included, four of them performed in Europe. Three studies evaluated NIPT as a contingent test, three studies evaluated a universal NIPT, and six studies evaluated both. The results are heterogeneous, especially for the contingent NIPT where the results range from NIPT being dominant to a dominated strategy. Universal NIPT was found to be more effective but also costlier than the usual screening, with very high incremental cost-effectiveness ratios. One advantage of screening with NIPT is lower invasive procedure-related foetal losses than with usual screening. In conclusion, the cost-effectiveness of contingent NIPT is uncertain according to several studies, while the universal NIPT is not cost-effective currently.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Síndrome de Down / Síndrome da Trissomia do Cromossomo 13 / Síndrome da Trissomía do Cromossomo 18 / Ácidos Nucleicos Livres Tipo de estudo: Diagnostic_studies / Health_economic_evaluation / Systematic_reviews Limite: Female / Humans / Pregnancy País/Região como assunto: Europa Idioma: En Revista: Eur J Health Econ Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Síndrome de Down / Síndrome da Trissomia do Cromossomo 13 / Síndrome da Trissomía do Cromossomo 18 / Ácidos Nucleicos Livres Tipo de estudo: Diagnostic_studies / Health_economic_evaluation / Systematic_reviews Limite: Female / Humans / Pregnancy País/Região como assunto: Europa Idioma: En Revista: Eur J Health Econ Ano de publicação: 2018 Tipo de documento: Article