Mast cell in innate immunity mediated by proinflammatory and antiinflammatory IL-1 family members.
J Biol Regul Homeost Agents
; 31(4): 837-842, 2017.
Article
em En
| MEDLINE
| ID: mdl-29254286
ABSTRACT
Innate immunity consists of physical and chemical barriers which provide the early defense against infections. Innate immunity orchestrates the defense of the host with cellular and biochemical proteins. Mast cells (MCs) are involved in innate and adaptive immunity and are the first line of defense which generates multiple inflammatory cytokines/chemokines in response to numerous antigens. MC-activated antigen receptor Fc-RI provokes a number of important biochemical pathways with secretion of numerous vasoactive, chemoattractant and inflammatory compounds which participate in allergic and inflammatory diseases. MCs can also be activated by Th1 cytokines and generate pre-formed and de novo inflammatory mediators, including TNF. IL-37 is an anti-inflammatory cytokine which binds IL-18R-alpha chain and reduces the production of inflammatory IL-1 family members. IL-37 down-regulates innate immunity by inhibiting macrophage response and its accumulation and reduces the cytokines that mediate inflammatory diseases. Here, we discuss the relationship between MCs, innate immunity, and pro-inflammatory and anti-inflammatory cytokines.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Interleucina-1
/
Receptores de Interleucina-1
/
Inflamação
/
Macrófagos
/
Mastócitos
Limite:
Humans
Idioma:
En
Revista:
J Biol Regul Homeost Agents
Ano de publicação:
2017
Tipo de documento:
Article