Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward.

Vadodaria, Krishna C; Amatya, Debha N; Marchetto, Maria C; Gage, Fred H

Vadodaria, Krishna C; Amatya, Debha N; Marchetto, Maria C; Gage, Fred H.

Afiliação

Vadodaria KC; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Amatya DN; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Marchetto MC; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Gage FH; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA. gage@salk.edu.

Genome Med ; 10(1): 1, 2018 01 04.

Article em En | MEDLINE | ID: mdl-29301565

ABSTRACT

ABSTRACT

Our understanding of the neurobiology of psychiatric disorders remains limited, and biomarker-based clinical management is yet to be developed. Induced pluripotent stem cell (iPSC) technology has revolutionized our capacity to generate patient-derived neurons to model psychiatric disorders. Here, we highlight advantages and caveats of iPSC disease modeling and outline strategies for addressing current challenges.

Assuntos

Células-Tronco Pluripotentes Induzidas/patologia; Transtornos Mentais/patologia; Modelos Biológicos; Neurônios/patologia; Animais; Humanos; Transtornos Mentais/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes Induzidas / Transtornos Mentais / Modelos Biológicos / Neurônios Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: Genome Med Ano de publicação: 2018 Tipo de documento: Article

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